• Liquids, liquid preparation
Low molecular weight polyethylene glycol is recommended for use in liquid preparations such as drops, injections and soft capsule contents due to its excellent solubility. Polyethylene glycol does not soften gelatin. The liquid peg has a bitter taste. Solid odorless.
• basics of the Ointment
Solid polyethylene glycol does not dissolve in liquid polyethylene glycol. Pasty or solid polyethylene glycol is mixed with liquid to form a white pasty ointment that is well soluble in water and compatible with many active ingredients (e.g. 40% Polyglykol 3350 + 60% Polyglykol 400). Ointment matrix containing polyethylene glycol can be used in combination with hexadecanol, hexadecanol, stearic acid, propylene glycol, glycerol, glycerol monostearate, polyoxyethylene sorbitan fatty acid ester.
• Suppositories suppository
Solid polyethylene glycol is an ideal suppository substrate. Many of the active ingredients can be dissolved in polyethylene glycol to give the drug good bioavailability. Different molecular weight ratios can produce different hardness (e.g., 25% PEG 1000 + 75% PEG 1500 S for a very soft matrix; Whereas 25% PEG 4000 S + 75% PEG 6000 S yields a near-solid matrix.
• Tablets Tablets
Polyethylene glycol has many applications in tablets. It can be used as the carrier of active ingredients, solvent and absorption promoter. This is usually achieved by molten pelletizing (limited to the active ingredient's resistance to 70 ° c). It can also be used as lubricant and adhesive in tablet production. It is suggested that at a lower melting point, the plasticizing effect of peg at the same time can promote the formation of tablets and prevent cracking, and increase plasticity. Solid polyethylene glycol can also be used in tablet coating, on the sugar coating can be used as an anti-adhesion agent; Polyethylene glycol can be used as a film forming agent on film coating.
• Ophthalmic demulophthalmology analgesics
Polyethylene glycol 300 and 400 were used as analgesics in ophthalmology, and the dosage was 0.2~1.0%. Polyethylene glycol 6000 is listed as an ophthalmic medication.
• Laxatives Laxatives
High water solubility based on polyethylene glycol and not absorbed by the human body, recommended for laxative (no side effects such as nausea and flatulence). The United States pharmacopoeia records details of "polyethylene glycol 3350 with oral electrolyte solution." Industrial generation is less recommended due to the fine powder level is not easy to mix with other electrolytes and the powder is easy to absorb moisture.
• Organ preservations
Linear high molecular weight polyethylene glycol (20000 Dalton) is particularly used to protect, maintain, or restore the function of cells, tissues, or organs. Long chains are more effective at fighting cell death than short chains. High molecular weight polyethylene glycol (peg) has a high tolerance in organ transplantation. Early evidence of resistance to protein penetration through cell membranes.
The hydroxyl group at the end of peg can react with alcohols, such as esterification, carbonation, carbamate, etc. Methoxy polyethylene glycol MPEG can react with terminal molecules to form new compounds. Polyethylene glycol has a wide range of cooperation with proteins, organic molecules, especially anticancer drugs. In the case of anticancer drugs, polyethylene glycol sometimes ACTS without binding to other molecules. Animal tests have shown that it has anti-colon cancer effects, can be extended to the human body.
Polyethylene glycol precipitates with the following substances, such as phenol, cresol, resorcinol, salicylic acid, cresol, tannic acid, potassium iodide, etc.
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